Synthetic Peptide for Kisspeptin Receptor (KISS1R / GPR54) Research

General Overview:

Kisspeptin-10 is a short neuropeptide that plays a key role in controlling the release of GnRH, the hormone that kickstarts the reproductive hormone cascade. Researchers use it to study fertility, the timing of puberty, and overall sexual health. It also helps scientists explore hormone therapies, reproductive medicine approaches, and the connections between metabolism and reproductive function in experimental models.

Technical Overview

Kisspeptin-10 (KP-10) 10mg is a synthetic decapeptide compound developed for laboratory research involving neuroendocrine signaling, GnRH/LH/FSH release pathways, receptor interaction analysis, and controlled experimental investigation. In research settings, this peptide is commonly utilized for studying KISS1R (also known as GPR54) binding affinity, downstream G-protein coupled receptor signaling in hypothalamic models, and related biochemical mechanisms.

Kisspeptin-10 is the C-terminal active fragment of the parent Kisspeptin protein encoded by the KISS1 gene. It binds the KISS1R receptor with sub-nanomolar to low-nanomolar affinity in both rodent and human receptor models. The peptide family was initially identified for tumor metastasis suppressor properties (KISS1 = "Kisspeptin Suppressor Sequence") before its central role in reproductive endocrinology was discovered through KISS1R loss-of-function studies.

Specifications

Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂Molecular Formula: C₆₃H₈₃N₁₇O₁₄Molecular Weight: 1302.45 g/molPurity: ≥ 99%CAS: 374675-21-5Form: Lyophilized powder

Research Use Only

This product is intended for laboratory research purposes only and is not for human or veterinary use, diagnostic procedures, or therapeutic application.